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This book provides a detailed examination of autoimmune conditions that are either life-threatening or require intricate management. It addresses acute symptoms such as abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke, and white-matter CNS lesions. The text explores current clinical and immunological prognostic factors that can help identify patients at higher risk for severe involvement. It aims to assist readers in diagnosing these patients, where early therapeutic intervention is crucial.